In the wake of Dynavax’s 3rd DSMB positive review, I complied a non-exhaustive list of current Merck Keytruda collaborations:
Dynavax:
SD-101 - Phase I/II by itself
activate TLR9 in DCs
http://investors.dynavax.com/releasedetail.cfm?releaseid=915694
Amgen:
Talimogene laherparepvec - Phase III by itself
Engineered HSV-1 to 1) kill cancer cells 2) activate DCs by making GM-CSF
http://wwwext.amgen.com/media/media_pr_detail.jsp?releaseID=2054439
Eli Lily:
Multiple compounds
https://investor.lilly.com/releasedetail.cfm?ReleaseID=890978
Oncosec:
Electroporation delivery of cDNA: IL-12, immune activator Phase II by itself
http://ir.oncosec.com/press-releases/detail/1634/uc-san-francisco-and-oncosec-medical-collaborate-to
Tesaro:
PARP-1/2 inhibitor - Phase III by itself
Inhibit DNA repair in cancer cells to induce apoptosis
http://ir.tesarobio.com/releasedetail.cfm?ReleaseID=915582
Nanostring:
Gene expression assay for precision treatment
http://investors.nanostring.com/releasedetail.cfm?ReleaseID=915259
Advaxis:
Lm-LLO Listeria vaccine for Immunotherapy - Approved by itself
Basically acting as TLR ligands. This is the oldest cancer immunotherapy idea.
http://ir.advaxis.com/press-releases/detail/744/advaxis-and-merck-form-collaboration-to-evaluate-investigational-combination-of-two-novel-immunotherapy-candidates-for-advanced-prostate-cancer
Syndax:
HDAC inhibitor, Phase III by itself
http://www.mercknewsroom.com/news-release/oncology-newsroom/syndax-and-merck-collaborate-immuno-oncology-study-evaluating-entinos
Tetralogic:
SMAC-Mimetic - IAP inhibitor Phase II by itself
inhibit proliferation and enhance apoptosis
http://ir.tetralogicpharma.com/releasedetail.cfm?releaseid=907283